Structure-activity correlations

It is a fundamental aspect of biochemistry that biological or biochemical activity depends on molecular structure. Enzyme specificity is but one of the numerous examples of this principle, which is integrated in most research projects in the group. This is also a major reason for the importance of elucidation of molecular structures in biochemistry.

 

 

 

 

 

Selected recent papers:

 

Søndergaard, M., Zhu, N., Lai, R.H., Jeffery, E.H., Sørensen, J.C., and Sørensen, H.: Comparative efficacy and safety of dietary glucoraphanine and broccoli in male F344 rats. In: Proceedings of Euro Food Chem XV Congress, ISBN 978-87-993033-4-2, Copenhagen, 5. – 8. July 2009, (2009) II, 1-5.

 

Bellostas, N., Sørensen, A.D., Sørensen, J.C., and Sørensen, H.: Type and concentration of redox reagents influencing nitrile formation upon myrosinase (Brassica carinata) enzymatic catalyzed hydrolysis of a model glucosibarinnolates. J. Mol. Catal. B: Enzym. (2009) 57, 229-236.

 

Niels Agerbirk, Suzanne I. Warwick, Carl Erik Olsen, Paul Robert Hansen, 2008. Sinapis phylogeny and evolution of glucosinolates and specific nitrile degrading enzymes. Phytochemistry 69, 2937-2949.

 

Bellostas, N., Sørensen, A.D., Sørensen, J.C. and Sørensen, H.: Fe²⁺- catalysed formation of nitriles and thionamides from intact glucosinolate. J. Natural Products (2008) 71, 76-80.

 

Bellostas, N., Petersen, I.L., Sørensen, J.C. and Sørensen, H.: A fast and gentle method for the isolation of myrosinase complexes from Brassicaceous seeds. J. Biochem. Biophys. Methods (2008), 70, 918-925.

 

Mikkelsen, T.L., Frøkiær, H., Topp, C., Bonomi, F., Iametti, S., Picariello, G., Ferranti, P & V.Barkholt (2005): Caseinomacropeptide Self-Association is Dependent on Whether the Peptide is Free or Restricted in -Casein. Dairy Sci. 88: 4228-4238.

 

H. Brønnum, T. Seested, Hellgren, L.I., Brix S. & H. Frøkiær (2005): Milk-derived GM3 and GD3 differentially inhibit dendritic cell maturation and effector functionalities. Scand. J. Immunol. 61: 551-557.

 

Bruun, S.W., Christenen, H.R. & H. Frøkiær (2003): Identification of soy proteins with oral immunogenicity. Int. Arch. Allergy Immunol. 132: 58-67.

 

Niels Agerbirk, Carl Erik Olsen, Bo M. Bibby, Hanne O. Frandsen, Lea D. Brown, Jens Kvist Nielsen, & J. Alan A. Renwick, 2003. A saponin correlated with variable resistance of Barbarea vulgaris, to the diamondback moth, Plutella xylostella. Journal of Chemical Ecology 29, 1417-1433.