Book: Peptide and Protein Design for Biopharmaceutical Applications

2009 October:

 

With Professor Knud J. Jensen as the editor of the book "Peptide and Protein Design for Biopharmaceutical Applications" (published by Wiley), and him also responsible for several chapters, the department would like to congratulate Knud.

 

The contents of the book:

 

Preface

 

List of Contributors

 

1. Introduction

Knud J. Jensen

 

2. Computational Approaches in Peptide and Protein Design: An Overview

Garland Marshall and Gregory Nikiforovich

2.1 Introduction

2.2 Basics and Tools

2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4

Acknowledgements

References

3. Aspects of Peptidomimetics

VeroniqueMaes and Dirk Tourwe

3.1 Introduction

3.2 Modified peptides

3.3 Pseudopeptides

3.4 Secondary structure mimics (excluding turn mimics)

3.5 Examples of Peptidomimetics

3.6 Conclusion

References

4. Design of Cyclic Peptides

Oliver Demmer, A. O. Frank, and Horst Kessler

4.1 Introduction

4.2 Peptide Cyclization

4.3 Conformation and Dynamics of Cyclic Peptides

4.4 Concepts in Rational Design of Cyclic Peptides

4.5 Examples of Cyclic Peptides as Drug Candidates

4.6 Conclusion

References

5. Carbohydrates in Design of Peptides and Proteins

Knud J. Jensen and Jesper Brask

5.1 Introduction

5.2 Configurational and conformational properties of carbohydrates

5.3 Carbohydrates in Peptidomimetics

5.4 Glycopeptides

5.5 Carbohydrates as scaffolds in the design of non-peptide peptidomimetics

5.6 Sugar amino acids
5.7 Cyclodextrin-peptide conjugates

5.8 Carboproteins: Model proteins on carbohydrate templates

5.9 Concluding remarks

6. De Novo design of proteins

Knud J. Jensen

6.1 Introduction

6.2 Secondary structure elements

6.3 Assembling a specified tertiary structure from secondary structure elements

6.4 Proteins on templates

6.5 Foldamers

6.6 Biopharmaceutical applications of protein de novo design

References

7. Design of insulin variants for improved treatment of diabetes

Thomas Høeg-Jensen

7.1 Introduction

7.2 Diabetes Management and the Need for Insulin Engineering

7.3 Insulin structure

7.4 Prolonged-acting insulin solids

7.5 Prolonged-acting insulin solutions

7.6 Fast-acting insulins

7.7 Glucose-sensitive insulin preparations

7.8 Alternative insulin delivery

7.9 Insulin mimetics

7.10 Pushing the limitations of insulin engineering

7.11 Outlook

References